LGC Standards has expanded its Dr. Ehrenstorfer PFAS portfolio with new 13C-labeled reference materials developed for U.S Environmental Protection Agency (EPA) Method 1633. The release includes two ready-to-use isotope-labeled internal standard mixtures—one with 24 analytes and another with seven analytes—as well as a broad selection of single compound solutions. These materials are intended to support calibration and improve data quality across water, solid, and tissue matrices.

Per- and polyfluoroalkyl substances (PFAS), also known as “forever chemicals,” are a group of over 1,200 synthetic chemicals used widely for industrial purposes and in consumer goods since the 1940s. Known for their persistence in the environment and resistance to degradation, PFAS accumulate in soil, water, animals, and humans, and have long biological half-lives. Exposure has been associated with developmental effects, immune system disruption, and certain cancers. Regulatory limits for PFAS are increasingly stringent, often set at parts-per-trillion levels, making accurate and traceable testing essential for environmental and public health protection.

EPA Method 1633A, issued in December 2024, is the only PFAS chemical testing method validated across multiple laboratories for a wide range of matrices, including wastewater, surface water, groundwater, landfill leachate, soil, sediment, biosolids, and fish or shellfish tissue.

The new LGC Standards mixtures include:

• EPA Method 1633 EIS Labeled PFAS Mixture (24 analytes; 0.25–5 micrograms per milliliter [µg/mL], 1 mL; Part No. DRE-A50000792MW), added before extraction to monitor sample preparation recovery.
• EPA Method 1633 NIS Labeled PFAS Mixture (seven analytes; 0.25–1 µg/mL, 1 mL; Part No. DRE-A50000794MW), added before injection to correct for instrument response.

Both mixtures are formulated for stability and routine use, helping laboratories reduce calibration frequency, account for matrix effects and instrument variability, and avoid the need to prepare in-house blends. They align with EPA Method 1633A’s prescribed values to support reliable quantitation and regulatory compliance.

 LGC Standards: www.lgcstandards.com.