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BIZTRACKS

EPA Approves First Protein-Based Biofungicide

By Food Safety Magazine Editorial Team
crops
Image credit: Simon Kan via Pexels
December 2, 2025

EVOCA, a new biofungicide from Biotalys, has received regulatory approval from the U.S. Environmental Protection Agency (EPA). The plant protection product was developed using Biotalys’ AGROBODY technology platform and is the first protein-based biofungicide of its kind to be approved by EPA.

At the end of October 2025, EPA also posted a final rule exempting EVOCA’s active ingredient residues on treated crops from tolerance requirements. No maximum residue limits will apply given EVOCA’s safety profile.

EVOCA is a precision biocontrol solution with a new mode of action, recognized by the Fungicide Resistance Action Committee (FRAC), that targets the fungal pathogens botrytis (grey mold) and powdery mildew in high-value fruits and vegetables while minimizing the risk to beneficial organisms or the environment.

With EPA’s approval, Biotalys will proceed with the dossiers for state registrations in California and Florida.

In Europe, EVOCA has entered the peer review phase. The Netherlands has proposed its approval in Europe, subject to the submission of certain additional data as requested during the peer review phase.

Additionally, the company can move forward with building up the U.S. regulatory submission for EVOCA NG, a next-generation product that is currently in the final phases of development. The regulatory review process for EVOCA NG is expected to be significantly shorter than for EVOCA, as the product contains the same active ingredient and features enhanced formulation and production methods. Biotalys hopes to secure registration of EVOCA NG in the U.S. by 2029 and in the EU and Brazil by 2030.

Biotalys positions EVOCA as a novel, sustainable solution for growers to protect their crops, with the flexibility for use in both pre- and post-harvest applications across a wide range of food crops in both greenhouse and outdoor growing conditions. The company also highlights its compatibility with an array of application methods and easy integration into existing farm management practices. Additionally, the new mode of action may help manage resistance buildup when compared with existing fungicides.

EPA’s documents regarding EVOCA can be read here.

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KEYWORDS: EPA fungicide

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The Food Safety Magazine editorial team comprises Bailee Henderson, Director of Content Strategy and news editor ✉, and Adrienne Blume, M.A., Director of Editorial and Industry Engagement.

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