Regarding MOSH, adverse effects on the liver were observed in a specific strain of rat, but the evidence suggests that these effects are not relevant for humans. Experts also looked at two different types of MOAH, concluding one may contain genotoxic substances that can damage DNA in cells and could be carcinogenic. It is not possible to establish a safe level for genotoxins identified in the MOAH substance.

Because little information is available on the occurrence of MOAH in food, EFSA also developed two different predictive scenarios, both of which indicated a possible health concern using a margin of exposure (MOE) approach. EFSA found that MOH can enter food in many ways—through environmental contamination, the use of lubricants for machinery, release agents, processing aids, food or feed additives, and migration into food from food contact materials.

The substances have been found in a variety of foods, which typically contain higher levels of MOSH than MOAH. The highest levels of MOH were found in vegetable oils, and the highest exposure was estimated for young people, especially infants who have been fed exclusively with infant formula containing high levels of MOSH.

Experts recommend that more research is done to quantify the presence of MOAH in food and that toxicity data are collected to better assess the associated risks. For MOSH, EFSA states that it is important to keep studying the possible long-term effects on human health.