The questions about the safety of controlled environment agriculture (CEA) are complicated. This article outlines why CEA safety depends on understanding and properly addressing the challenges of combining agricultural and ready-to-eat (RTE) into a single facility. It also addresses why CEA is not inherently safe. Ultimately, this article will show how the risk profile of CEA must be compared to that of other RTE produce and that there is no universal answer to the question of CEA safety.