The direct final rule completes administrative actions that reflect the agency’s June 2015 final determination on the GRAS status of PHOs. In the 2015 final determination, FDA indicated that there were outdated references to PHOs in regulations that the agency would address separately. With respect to removing PHOs from the food supply, FDA established January 1, 2021, as the final compliance date to allow manufacturers time to reformulate foods and ensure an orderly transition in the marketplace.