On World Food Safety Day on 7 June 2021, the European Food Safety Agency launched its new risk communication campaign entitled “Choose Safe Food” to encourage people to think critically about their everyday food choices. This brought to mind my experience at the World Health Organization (WHO) about fashioning global food safety messages, which presented several challenges. Firstly, the potential audience is vast (8.8 billion of us!). Among them are hundreds of millions of people all along the food supply chain who can have a positive or negative impact on the safety of food as well as consumers who prepare meals in the home. Secondly, both the foods and the audience are diverse. Obviously, basic food commodities, ingredients, and cuisines vary greatly across the world. In addition, food safety messages for a global audience would have to take into account the cultural, social, and economic differences among regions of the world. However, groups, such as those vulnerable to foodborne diseases and schoolchildren, have a particular need to know about food safety. Finally, risk communicators themselves should be aware of the uncertainties in the science underlying food safety as well as their own potential biases.