In the ever-evolving landscape of food, beverage, and other ingestible product industries, pathogen control emerges as one of the most pressing challenges. Today, we turn our attention to a promising solution: chlorine dioxide gas. We will delve into its effectiveness in resetting the environment and eliminating pathogens, highlight research that underscores its utility, and propose ways in which this technology can be seamlessly integrated into existing food safety protocols. 

The Challenge of Pathogen Control 

The food industry is no stranger to the threat of pathogens. From bacteria like Salmonella and Listeria to viruses and fungi, these microscopic invaders can wreak havoc on food safety and quality. The consequences of a pathogen outbreak are severe, ranging from public health crises to costly product recalls.

Recent years have seen an increase in food recalls due to pathogen contamination, driven by factors such as the global and complex food supply chain, heightened regulatory oversight, and increased media coverage. The average cost of a recall to a food company is $10 million in direct costs, not to mention the damage to the brand and lost sales.

The Solution: Chlorine Dioxide Gas 

Enter chlorine dioxide gas, a powerful, EPA-registered sterilant that has shown promising results in reducing pathogen load in food manufacturing environments. Chlorine dioxide gas works by penetrating the cell wall of microorganisms and disrupting the metabolic functions, leading to the death of the pathogen.

A study by Y. Ran, C. Qingmin, and F. Maorun titled, "Chlorine Dioxide Generation Method and its Action Mechanism for Removing Harmful Substances and Maintaining Quality Attributes of Agricultural Products,"1 systematically evaluated the performance of chlorine dioxide in maintaining food safety and freshness of agricultural products. The study found that chlorine dioxide, alone and in combination with other treatments, effectively reduced the pathogen load and preserved the quality of the food products.

Another study, "The Effect of Controlled-Release Chlorine Dioxide on the Preservation of Grapefruit,"2 by Xiuxiu Sun and colleagues, found that slow-release treatment of chlorine dioxide exhibited the best antimicrobial activity, reducing total aerobic bacterial count and yeast/mold count, and maintained the best visual, sensory, and overall quality of grapefruit.

These studies, among others, provide compelling evidence of the effectiveness of chlorine dioxide gas in pathogen reduction, making it a valuable tool for food safety professionals.

Integrating Chlorine Dioxide Gas into Food Safety Protocols 

The integration of chlorine dioxide gas into existing food safety protocols can be a game-changer for food manufacturers. This technology can be used in various stages of the food production process, including sanitizing processing equipment and storage facilities, particularly when bacteria counts reach unmanageable levels through normal sanitizing processes.

The use of chlorine dioxide gas does not replace the need for good manufacturing practices (GMPs) and adherence to Hazard Analysis and Critical Control Points (HACCP) principles. Instead, it complements these practices by providing an additional layer of protection against pathogens by resetting the environment of bacteria and harmful microbes. Chlorine dioxide gas has been found to reduce microbes at 6-log, or by 99.999 percent, as validated by biological indicators.

Chlorine dioxide is also used in post-construction to ensure that startup takes place in a pathogen-free environment, regardless of whether the project is updating the hygienic design of a current building or new construction.

The Future of Food Safety 

The food industry is continually evolving; so, too, are the challenges it faces. As we strive to ensure the safety and quality of our food, it is crucial to stay ahead of the latest research and technological advancements. Chlorine dioxide gas represents a promising solution to the ongoing challenge of pathogen control, backed by scientific research and proven results.

Food safety professionals must continue to explore and adopt effective solutions to protect our food supply, our businesses, and our consumers. After all, the future of food safety depends on our actions today.

PureLine's Chlorine Dioxide Fumigation Treatments

If you are a food safety professional looking for a proven, effective solution to pathogen control, PureLine can help. Our chlorine dioxide fumigation services are designed to reset the pathogenic environment of food plants for emergency remediation needs and post-construction. PureLine has a 30-plus-year history and track record of success in helping food and beverage businesses ensure the safety and quality of their products through sanitized environments.

To find out if chlorine dioxide fumigation is right for your business, do not hesitate to reach out to us. You can call PureLine at 847-963-8465, or email us at

Our team of experts is ready to answer your questions and provide the support you need to enhance your food safety protocols.

Remember, the future of food safety depends on the actions we take today. Let PureLine be your partner in creating a safer, healthier future for your business and your customers.


1 Ran, Y., C. Qingmin, and F. Maorun. "Chlorine Dioxide Generation Method and its Action Mechanism for Removing Harmful Substances and Maintaining Quality Attributes of Agricultural Products." Food and Bioprocess Technology 12 (April 2019): 1110–1122.

2 Sun, X., E. Baldwin, C. Ference, J. Narciso, A. Plotto, M. Ritenour, K. Harrison, D. Gangemi, and J. Bai. "The Effect of Controlled-Release Chlorine Dioxide on the Preservation of Grapefruit." HortScience 52, no. 1 (January 2017): 122–126.